XIAP (NM_001167) Human Untagged Clone

CAT#: SC119404

XIAP (untagged)-Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: XIAP
• Synonyms: API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119404 sequence for NM_001167 edited (data generated by NextGen Sequencing)
  ATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAATAAGGAA
  GAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGT
  CCTGTTTCAGCATCAACACTGGCACGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACC
  GTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCAGCAGTT
  GGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAAT
  AGTGCCACGCAGTCTACAAATTCTGGTATCCAGAATGGTCAGTACAAAGTTGAAAACTAT
  CTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGACTATCTT
  TTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATG
  TATAGTGAAGAAGCTAGATTAAAGTCCTTTCAGAACTGGCCAGACTATGCTCACCTAACC
  CCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTGCAGTGC
  TTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACAC
  AGGCGACACTTTCCTAATTGCTTCTTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAA
  TCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGAAATCCA
  TCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAAC
  AAGGAGCAGCTTGCAAGAGCTGGATTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGC
  TTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAACAACAT
  GCTAAATGGTATCCAGGGTGCAAATATCTGTTAGAACAGAAGGGACAAGAATATATAAAC
  AATATTCATTTAACTCATTCACTTGAGGAGTGTCTGGTAAGAACTACTGAGAAAACACCA
  TCACTAACTAGAAGAATTGATGATACCATCTTCCAAAATCCTATGGTACAAGAAGCTATA
  CGAATGGGGTTCAGTTTCAAGGACATTAAGAAAATAATGGAGGAAAAAATTCAGATATCT
  GGGAGCAACTATAAATCACTTGAGGTTCTGGTTGCAGATCTAGTGAATGCTCAGAAAGAC
  AGTATGCAAGATGAGTCAAGTCAGACTTCATTACAGAAAGAGATTAGTACTGAAGAGCAG
  CTAAGGCGCCTGCAAGAGGAGAAGCTTTGCAAAATCTGTATGGATAGAAATATTGCTATC
  GTTTTTGTTCCTTGTGGACATCTAGTCACTTGTAAACAATGTGCTGAAGCAGTTGACAAG
  TGTCCCATGTGCTACACAGTCATTACTTTCAAGCAAAAAATTTTTATGTCTTAA
  
  Clone variation with respect to NM_001167.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001167 unedited
  GGTAGGATTTTGTAACACGATTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCCAAGC
  CGTAGAGCGGAGTTGGCATTTCCAGATTGGGGCTCGGGCCGCGCCTCCTCCGGGACCCTC
  CCCTTGGACCGAGCCGATCGCCGCGGGGCAGTTCGGGCCGGCTGTCCTGGCGCGAAAAGG
  TGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTT
  GTGTACCTGCAGACATCAATAAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAA
  CTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCACGAGCAGGGT
  TTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATA
  GATGGCAATATGGAGACTCAGCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGAT
  TTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCTGGTATCCAGA
  ATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGC
  CATCTGAGACACATGCAGACTATCTTTTGAGAACTGNGCAGGTTGTAGATATATCAGACA
  CCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAAGTCCTTTCAG
  AACTGCCCAGACTATGCTCACCTAACCCCAGAGAGTTAGCCAGTGCTGGACTCTACTACA
  CAGGTATTGGTGACCAAGTGCAGTGCTTTTTGTTGTGGTGGAAAACTGAAAAAATGGGAA
  CCTGTGATCGTGCCTTGGTCAGACACAAGCGACACTTNTCCTAATTGCTTCTTTGGTTGG
  GGCCNGNATTCTTATATTCGAATGAAATTGAGGCTGGGAGGTCTGATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001167 unedited
  CGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTAAGGATCTTGAGAGAACAT
  TTATTTCAGAAGTATCTACTACTATTACTAGCCAAGAAAACAAATGTAGGTAGAGGAAAG
  ACTTAACATTTTGTCCTATATACATCTTAATCATCCTAATGGTAAAAACTCACATGAAAC
  TTTAAGATACAAGATGATATGAGAATCTCAACATGGAAAGCTGTCACTATAACTACAAGC
  AGTGTACAAACATGCTTCTACTTTTACCTACATAAGCTGACAGATGTTTAAAATACTGAG
  TTAACAAAGATCTTTTAGTAAAGTGACTTAGGCAGGCTTAAACTAGCAAGGATTAAGGAT
  GAATCCTTACTAATTAATTGGAAGATCTGAGACATATTTTATATTTCATTTTACAAAATC
  AGAAATACTTATTTTGAAACAAGATAAGACATGGTCTACCTGTCAAAAAACTACCACTCA
  GAAATATTTTTCATCCACAAAGCAGGAAAAACATAAAATCATTTACATTTCACATTGGCA
  CCAAAAAGGTTAACTGCCCTGCCTTCTTGGATTAGAAAAACTAAAGCTGAGTGATAAGTA
  GTTTTGCAGGCGTTTGAACATGCCTAAGCCTTTAAATCAGCAAAATACTTTCTAAAAATT
  CTGATTACAAAAGTAATACATACTTATAAAAAATTCGAACAGAACAAAATGAAAAAAGTA
  GAAGGTGGAAAAGGGCCCCTATAAAACCCCTATGGNGCCCTTTCCCCCCAATTCCCNCCC
  TTCCCGGAAGAGAAACCACATTTTACAGNNTTGGTGTATATCTTTCCAAATCTTTTGNTC
  TATGCATATTAAAACATACATACTTTGATCTGGCTAGACTTACATAGTGNNTTGCCACTG
  CATTTACACTTAACATATCTTGACATCTTCATGTAGTACATGTGGCTCGATAGATCTATC
  ATAATACGCTTCAAAATGCAATACC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001167
• Insert Size: 3000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001167.2, NP_001158.2
• RefSeq Size: 8413 bp
• RefSeq ORF: 1494 bp
• Locus ID: 331
• UniProt ID: P98170
• Cytogenetics: Xq25
• Domains: BIR, RING
• Protein Families: Druggable Genome
• Protein Pathways: Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
  Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.