OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home TrueClone ZAP70 Clone

ZAP70 (NM_001079) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323675 ZAP70 (untagged)-Kinase deficient mutant (K369M) of Human zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1 (10ug), NM_001079.3, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA318770 Anti-ZAP70 Mouse Monoclonal Antibody, 50ul $345 3-7 Days
Add to Shopping Cart
Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL4 Insert Size: Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseDruggable Genome
Protein Pathways: Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayPrimary immunodeficiency
Reference Data
RefSeq: NM_001079.3, NP_001070
RefSeq Size: 2450 RefSeq ORF: 1860
Synonyms : SRK; STCD; STD; TZK; ZAP-70
LocusID: 7535 Cytogenetic: 2q12
Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

bar
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title