OriGene - ERBB2 (NM_001005862) cDNA Clone

OriGene Data

Vector:	pCMV6-XL4	Insert Size: 4000	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Annotation:	The open reading frame of this clone has been fully sequenced and found one SNP within the protein associated with this reference, NM_001005862.1. This SNP results in a P to L change.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Protein Kinase Transmembrane Druggable Genome
Protein Pathways:	ErbB signaling pathway Calcium signaling pathway Focal adhesion Adherens junction Pathways in cancer Pancreatic cancer More Pathways >>

Reference Data

RefSeq: NM_001005862.1, NP_001005862	RefSeq Size: 4816	RefSeq ORF: 3678
Synonyms : CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
LocusID: 2064	Cytogenetic: 17q12
Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) contains additional exons at its 5' end and lacks an alternate 5' noncoding exon, compared to variant 1. These differences result in translation initiation at an in-frame, downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.

TrueClone Citations:

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST, Shiteshu Shrimal, Steven F. Trueman, and Reid Gilmore, J. Cell Biol., Apr 2013; 201: 81 - 95. [CD40]

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1, Edward B. Maryon, Shannon A. Molloy, and Jack H. Kaplan, Am J Physiol Cell Physiol, Apr 2013; 304: C768 - C779. [CSS]

B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma, Robert O. Carpenter, Moses O. Evbuomwan, Stefania Pittaluga, Jeremy J. Rose, Mark Raffeld, Shicheng Yang, Ronald E. Gress, Frances T. Hakim, and James N. Kochenderfer, Clin. Cancer Res., Apr 2013; 19: 2048 - 2060. [BCMA ]

Retinoic Acid Receptor ß Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice, Yu Li, Kimberly Wong, Kenneth Walsh, Bin Gao, and Mengwei Zang, J. Biol. Chem., Apr 2013; 288: 10490 - 10504. [FGF21 ]

Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation, Naveen L. Pereira, Dong Lin, Linda Pelleymounter, Irene Moon, Gail Stilling, Bruce W. Eckloff, Eric D. Wieben, Margaret M. Redfield, John C. Burnett, Jr, Vivien C. Yee, and Richard M. Weinshilboum, Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene, Hui Wei, Tapan K. Bera, Alan S. Wayne, Laiman Xiang, Simona Colantonio, Oleg Chertov, and Ira Pastan, J. Biol. Chem., Apr 2013; 288: 12305 - 12312. [WDR85]

Arachidonic Acid–Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4-Mediated Ca2+ Entry, Xiaodong Zheng, Natalya S. Zinkevich, Debebe Gebremedhin, Kathryn M. Gauthier, Yoshinori Nishijima, Juan Fang, David A. Wilcox, William B. Campbell, David D. Gutterman, and David X. Zhang, JAHA, Apr 2013; 2: e000080. [TRPV4 ]

Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines, Urszula Oleksiewicz, Triantafillos Liloglou, Kalliopi-Maria Tasopoulou, Nikoleta Daskoulidou, Julie Bryan, John R. Gosney, John K. Field, and George Xinarianos, Hum. Mol. Genet., Apr 2013; 10.1093/hmg/ddt174. [CYGB ]

Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response, Vincentius A. Halim, Mónica Alvarez-Fernández, Yan Juan Xu, Melinda Aprelia, Henk W. P. van den Toorn, Albert J. R. Heck, Shabaz Mohammed, and René H. Medema, Sci. Signal., Apr 2013; 6: rs9. [SPAG5]

More TrueClone Citations >>

ERBB2 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC224084	Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) as transfection-ready DNA	10 ug	$1510	Next day
MC220688	Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), as transfection-ready DNA	10 ug	$850	2 weeks
MR227307	Myc-DDK-tagged ORF clone of Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) as transfection-ready DNA	10 ug	$1510	6 weeks
MR210207	Myc-DDK-tagged ORF clone of Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), as transfection-ready DNA	10 ug	$850	Next day
MG227307	GFP-tagged ORF clone of Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) as transfection-ready DNA	10 ug	$1660	6 weeks
MG210207	GFP-tagged ORF clone of Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), in a GFP expression vector	10 ug	$940	Next day

ERBB2 Rat Clones

SKU	Description	Amount	Price	Shipping
RN205833	NativeORF clone of Rattus norvegicus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) as transfection-ready DNA	10 ug	$1890	Next day
RR205833	Myc-DDK-tagged ORF clone of Rattus norvegicus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) as transfection-ready DNA	10 ug	$1890	6 weeks

Don't see the species of your interest?
Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

ERBB2 (NM_001005862) Human cDNA Clone

TrueClone Citations:

ERBB2 Mouse Clones

ERBB2 Rat Clones

Product Manuals

MSDS

FAQs