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Home TrueClone RUNX1 Clone

RUNX1 (NM_001001890) Human cDNA Clone

Specifications Citations (4) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC106348 RUNX1 (untagged)-Human runt-related transcription factor 1 (RUNX1), transcript variant 2 (10ug), NM_001001890.1, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA306772 Rabbit Polyclonal RUNX1 Antibody, 100ug $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL4 Insert Size: 1700 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001001890.1.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: ES Cell Differentiation/IPSTranscription FactorsDruggable Genome
Protein Pathways: Pathways in cancerChronic myeloid leukemiaAcute myeloid leukemia
Reference Data
RefSeq: NM_001001890.1, NP_001001890
RefSeq Size: 7288 RefSeq ORF: 1362
Synonyms : AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB
LocusID: 861 Cytogenetic: 21q22.3
Summary: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (AML1b) is shorter and has a distinct N-terminus compared to isoform AML1c.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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