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Home TrueClone NR3C1 Clone

NR3C1 (NM_000176) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC120032 NR3C1 (untagged)-Human nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1), transcript variant 1 (10ug), NM_000176.2, 10ug $185 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA311010 Rabbit Monoclonal antibody against Glucocorticoid Receptor (NR3C1), 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 3700 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Nuclear Hormone ReceptorTranscription FactorsDruggable Genome
Protein Pathways: Neuroactive ligand-receptor interaction
Reference Data
RefSeq: NM_000176.2, NP_000167
RefSeq Size: 6784 RefSeq ORF: 2334
Synonyms : GCCR; GCR; GCRST; GR; GRL
LocusID: 2908 Cytogenetic: 5q31.3 Domains: hormone_rec, GCR, zf-C4
Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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