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Home TrueClone INS Clone

INS (BC005255) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC128255 INS (untagged)-Human insulin (cDNA clone MGC:12292 IMAGE:3950204), complete cds (10ug), BC005255.1, 10ug $185 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA317878 Insulin Mouse Monoclonal (2D11.H5) Antibody, 50ug $345 3-7 Days
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 500 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Secreted ProteinES Cell Differentiation/IPSDruggable Genome
Protein Pathways: Oocyte meiosisRegulation of autophagymTOR signaling pathwayRegulation of actin cytoskeletonInsulin signaling pathwayProgesterone-mediated oocyte maturationMore Pathways >>
Reference Data
RefSeq: BC005255.1, AAH05255
RefSeq Size: 495 RefSeq ORF: 333
Synonyms : ILPR; IRDN; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196038; proinsulin; Insulin
LocusID: 3630 Cytogenetic: 11p15.5
Summary: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].


* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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