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Home TrueClone PLCG1 Clone

PLCG1 (NM_182811) Human cDNA Clone

Specifications Citations (2) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC107651 PLCG1 (untagged)-Human phospholipase C, gamma 1 (PLCG1), transcript variant 2 (10ug) NM_182811.1, 10ug $980 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA307422 Rabbit monoclonal antibody against Phospho PLC gamma I (pY1245) (clone EP1502Y ) (Phospho-Specific), 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL4 Insert Size: 6300 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Druggable Genome
Protein Pathways: Inositol phosphate metabolismMetabolic pathwaysErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVEGF signaling pathwayMore Pathways >>
Reference Data
RefSeq: NM_182811.1, NP_877963
RefSeq Size: 5202 RefSeq ORF: 3873
Synonyms : NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
LocusID: 5335 Cytogenetic: 20q12
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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