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Home TrueClone RAD50 Clone

RAD50 (NM_133482) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC315241 RAD50 (untagged)-Human RAD50 homolog (S. cerevisiae) (RAD50), transcript variant 2 (10ug), NM_133482.1, 10ug $680 5 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA310802 Rabbit Monoclonal antibody against Rad50, 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL Insert Size: Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Druggable Genome
Protein Pathways: Homologous recombinationNon-homologous end-joining
Reference Data
RefSeq: NM_133482.1, NP_597816
RefSeq Size: 5826 RefSeq ORF: 3522
Synonyms : hRad50; NBSLD; RAD50-2;RAD50-2; OTTHUMP00000065928; RAD50 homolog; RAD50 homolog (S. cerevisiae)
LocusID: 10111 Cytogenetic: 5q31 Domains: Rad50_zn_hook
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010].

Transcript Variant: This variant (2) lacks an internal fragment, which leads to a translation frame shift when compared to variant 1. Translation begins at a down-stream start codon, and thus results in a protein that is 139 aa shorter at its N-terminus, as compared to isoform 1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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