ORAI1 (NM_032790) Human cDNA Clone

Vector:	pCMV6-AC	Insert Size:	Restriction Site: EcoRI-XhoI
Sequence Data:	Fully Sequenced ORF          5' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Transmembrane
Protein Pathways:

The use of this clone has been cited in the following citations:

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Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome, Brooke Burns, Kristie Schmidt, Stephen R. Williams, Sun Kim, Santhosh Girirajan, and Sarah H. Elsea, Hum. Mol. Genet., Aug 2010; 10.1093/hmg/ddq317 [ORAI1]

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TRPC channels function independently of STIM1 and Orai1, Wayne I. DeHaven, Bertina F. Jones, John G. Petranka, Jeremy T. Smyth, Takuro Tomita, Gary S. Bird, and James W. Putney, Jr, J. Physiol., May 2009; 587: 2275 - 2298. [Orai1]

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Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3, Shenyuan L. Zhang, J. Ashot Kozak, Weihua Jiang, Andriy V. Yeromin, Jing Chen, Ying Yu, Aubin Penna, Wei Shen, Victor Chi, and Michael D. Cahalan, J. Biol. Chem., Jun 2008; 283: 17662 - 17671. [ORAI1]

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Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line, Hong-Tao Ma, Ze Peng, Takaaki Hiragun, Shoko Iwaki, Alasdair M. Gilfillan, and Michael A. Beaven, J. Immunol., Feb 2008; 180: 2233 - 2239. [Orai1]

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Orai proteins interact with TRPC channels and confer responsiveness to store depletion., Y Liao, C Erxleben, E Yildirim, J Abramowitz, DL Armstrong, and L Birnbaumer, Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4682-7. [ORAI1]

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Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1, Jason C. Mercer, Wayne I. DeHaven, Jeremy T. Smyth, Barbara Wedel, Rebecca R. Boyles, Gary S. Bird, and James W. Putney, Jr, J. Biol. Chem., 2006 Aug 25;281(34):24979-90. [ORAI1]

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Orai1 and STIM Reconstitute Store-operated Calcium Channel Function, Jonathan Soboloff, Maria A. Spassova, Xiang D. Tang, Thamara Hewavitharana, Wen Xu, and Donald L. Gill, J. Biol. Chem., Jul 2006; 281: 20661-20665. [ORAI1]

More TrueClone Citations >>

ORAI1 Mouse Clones

ORAI1 Rat Clones

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Product Manuals

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• TrueClones: Human Full-Length cDNA Clones - 10 ug
• TrueClones: Mouse Full-Length cDNA Clones - 10 ug
• Transfection - TurboFectin 8.0 Transfection Reagent
• Plasmid Preparation - PowerPrep Plasmid Purification Kits

 

MSDS

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• TrueClone MSDS

 

FAQs

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• TrueClone FAQs
• Transfection Reagent