ORAI1 (NM_032790) Human cDNA Clone

Vector:	pCMV6-XL5	Insert Size: 1400	Restriction Site:
Sequence Data:	Fully Sequenced ORF          5' Read Nucleotide Sequence
OTI Annotation:	The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Transmembrane
Protein Pathways:

The use of this clone has been cited in the following citations:

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POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters , Grigory Krapivinsky, Luba Krapivinsky, Stephanie C. Stotz, Yunona Manasian, and David E. Clapham, PNAS, Nov 2011; 108: 19234 - 19239. [ORAI1 ]

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Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+ Release-activated Ca2+ (CRAC) Channels, Pulak Kar, Charmaine Nelson, and Anant B. Parekh, J. Biol. Chem., Apr 2011; 286: 14795 - 14803 [Orai1]

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Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis, Jeremy T. Smyth, John G. Petranka, Rebecca R. Boyles, Wayne I. DeHaven, Miwako Fukushima, Katina L. Johnson, Jason G. Williams & James W. Putney Jr, Nature Cell Biology Published online: 1 November 2009 | doi:10.1038/ncb1995 [ORAI1]

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Capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, Agnes CL Martin, Debbie Willoughby, Antonio Ciruela, Laura-Jo Ayling, Mario Pagano, Sebastian Wachten, Anders Tengholm, and Dermot MF Cooper, Mol. Pharmacol., Jan 2009; 10.1124/mol.108.051748. [ORAI]

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Voltage Gating at the Selectivity Filter of the Ca2+ Release-activated Ca2+ Channel Induced by Mutation of the Orai1 Protein, Maria A. Spassova, Thamara Hewavitharana, Richard A. Fandino, Asli Kaya, Jacqueline Tanaka, and Donald L. Gill, J. Biol. Chem. 2008; 283(22): p. 14938-14945 [Orai1]

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Store-dependent and -independent modes regulating CRAC channel activity of human Orai1 and Orai3, Shenyuan L Zhang, J. Ashot Kozak, Weihua Jiang, Andriy V. Yeromin, Jing Chen, Ying Yu, Aubin Penna, Wei Shen, Victor Chi, and Michael D. Cahalan, J. Biol. Chem., Apr 2008; 10.1074/jbc.M801536200 [ORAI1]

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Calcium inhibition and calcium potentiation of orai1, orai2 and orai3 calcium-release-activated calcium channels., Wayne I Dehaven, Jeremy T Smyth, Rebecca R Boyles, and James W Putney Jr, J Biol Chem. 2007 Jun 15;282(24):17548-56. [ORAI1]

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ORAI1 Mouse Clones

ORAI1 Rat Clones

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Product Manuals

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• TrueClones: Human Full-Length cDNA Clones - 10 ug
• TrueClones: Mouse Full-Length cDNA Clones - 10 ug
• Transfection - TurboFectin 8.0 Transfection Reagent
• Plasmid Preparation - PowerPrep Plasmid Purification Kits

 

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• TrueClone MSDS

 

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