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Home TrueClone TMPRSS3 Clone

TMPRSS3 (NM_032401) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC110610 TMPRSS3 (untagged)-Human transmembrane protease, serine 3 (TMPRSS3), transcript variant B (10ug), NM_032401.1, 10ug $580 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA315740 Rabbit polyclonal anti-TMPRSS3 antibody, 100ul $325 In Stock
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 2290 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: TransmembraneProteaseDruggable Genome
Reference Data
RefSeq: NM_032401.1, NP_115777
RefSeq Size: 2554 RefSeq ORF: 984
Synonyms : DFNB8, DFNB10, ECHOS1, TADG12;DFNB10; DFNB8; ECHOS1; TADG12; OTTHUMP00000109345; serine protease TADG12; transmembrane protease, serine 3
LocusID: 64699 Cytogenetic: 21q22.3 Domains: Tryp_SPc
Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].

Transcript Variant: This variant (B) lacks exons 1 and 2, but contains 384 nt of intron 2 preceding exon 3, possibly through the use of an alternative splice donor site. As a result, this variant lacks the exon 2 start codon and translation begins at a downstream in-frame start codon. The encoded protein has a 127 aa shorter N-terminus, as compared to isoform 1, and is identical to the protein encoded by variant C.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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