OriGene - SPRY4 (NM_030964) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 2500	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Annotation:	The ORF of this clone has been fully sequenced and found to be a perfect match to NM_030964.2.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:
Protein Pathways:	Jak-STAT signaling pathway

Reference Data

RefSeq: NM_030964.2, NP_112226	RefSeq Size: 4934	RefSeq ORF: 969
Synonyms : sprouty homolog 4; sprouty homolog 4 (Drosophila)
LocusID: 81848	Cytogenetic: 5q31.3	Domains: Sprouty
Summary: SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008]. Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).

TrueClone Citations:

Dihydrotestosterone and Bicalutamide Do Not Affect Periostin Expression in Androgen-dependent LNCaP Prostate Cancer Cell Lines, FRANCESCA ARGELLATI, PIER VITALE NUZZO, FRANCESCO RICCI, ROSA MANGERINI, ALESSANDRA RUBAGOTTI, and FRANCESCO BOCCARDO, Anticancer Res, Mar 2013; 33: 815 - 820. [POSTN]

An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart, Eva Tritsch, Youssef Mallat, Florence Lefebvre, Nicolas Diguet, Brigitte Escoubet, Jocelyne Blanc, Leon J. De Windt, Daniele Catalucci, Grégoire Vandecasteele, Zhenlin Li, and Mathias Mericskay, Cardiovasc Res, Mar 2013; 10.1093/cvr/cvt042. [JunD]

CSF1R mutations link POLD and HDLS as a single disease entity, Alexandra M. Nicholson, Matt C. Baker, NiCole A. Finch, Nicola J. Rutherford, Christian Wider, Neill R. Graff-Radford, Peter T. Nelson, H. Brent Clark, Zbigniew K. Wszolek, Dennis W. Dickson, David S. Knopman, and Rosa Rademakers, Neurology, Mar 2013; 80: 1033 - 1040. [CSF1R ]

Induced CYP3A4 Expression in Confluent Huh7 Hepatoma Cells as a Result of Decreased Cell Proliferation and Subsequent Pregnane X Receptor Activation, Louise Sivertsson, Irene Edebert, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, and Etienne P. A. Neve, Mol. Pharmacol., Mar 2013; 83: 659 - 670. [NR1I2 ]

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members, Alexis Verger, Jean-Luc Baert, Kathye Verreman, Frédérique Dewitte, Elisabeth Ferreira, Zoé Lens, Yvan de Launoit, Vincent Villeret, and Didier Monté, Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt199. [MED25]

Centaurin-a1-Ras-Elk-1 Signaling at Mitochondria Mediates ß-Amyloid-Induced Synaptic Dysfunction, Erzsebet M. Szatmari, Ana F. Oliveira, Elizabeth J. Sumner, and Ryohei Yasuda, J. Neurosci., Mar 2013; 33: 5367 - 5374. [APP]

Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion, Henrik Dimke, Prajakta Desai, Jelena Borovac, Alyssa Lau, Wanling Pan, and R. Todd Alexander, Am J Physiol Renal Physiol, Mar 2013; 304: F761 - F769. [Cldn14]

Mechanisms by which the orexigen NPY regulates anorexigenic a-MSH and TRH, Nicole E. Cyr, Anika M. Toorie, Jennifer S. Steger, Matthew M. Sochat, Samantha Hyner, Mario Perello, Ronald Stuart, and Eduardo A. Nillni, Am J Physiol Endocrinol Metab, Mar 2013; 304: E640 - E650. [NYP1R]

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway, David R. Croucher, Falko Hochgräfe, Luxi Zhang, Ling Liu, Ruth J. Lyons, Danny Rickwood, Carole M. Tactacan, Brigid C. Browne, Naveid Ali, Howard Chan, Robert Shearer, David Gallego-Ortega, Darren N. Saunders, Alexander Swarbrick, and Roger J. Daly, Cancer Res., Mar 2013; 73: 1969 - 1980. [SGK269 ]

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SPRY4 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC209697	Mus musculus sprouty homolog 4 (Drosophila) (Spry4) as transfection-ready DNA	10 ug	$380	3 weeks
MR204177	Myc-DDK-tagged ORF clone of Mus musculus sprouty homolog 4 (Drosophila) (Spry4) as transfection-ready DNA	10 ug	$380	Next day
MG204177	GFP-tagged ORF clone of Mus musculus sprouty homolog 4 (Drosophila) (Spry4) in a GFP expression vector	10 ug	$420	3 weeks

SPRY4 Rat Clones

SKU	Description	Amount	Price	Shipping
RN214598	NativeORF clone of Rattus norvegicus sprouty homolog 4 (Drosophila) (Spry4) as transfection-ready DNA	10 ug	$380	3 weeks
RR214598	Myc-DDK-tagged ORF clone of Rattus norvegicus sprouty homolog 4 (Drosophila) (Spry4) as transfection-ready DNA	10 ug	$380	3 weeks

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SPRY4 (NM_030964) Human cDNA Clone

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SPRY4 Mouse Clones

SPRY4 Rat Clones

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