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Home TrueClone NAIP Clone

NAIP (NM_022892) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC315876 NAIP (untagged)-Human NLR family, apoptosis inhibitory protein (NAIP), transcript variant 2, NM_022892.1, 10ug $2310 3 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA306166 Rabbit Polyclonal NAIP Antibody, 100ug $325 3-7 Days
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OriGene Data
Vector: pCMV6-Entry QM Insert Size: Restriction Site: SgfI-MluI
Sequence Data: Fully Sequenced ORF         
OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Druggable Genome
Protein Pathways: NOD-like receptor signaling pathway
Reference Data
RefSeq Explanation: NM_022892.1, NP_075043
RefSeq Size: 5880 RefSeq ORF: 3726
Synonyms : BIRC1; NLRB1; psiNAIP
LocusID: 4671 Cytogenetic: 5q13.2
Gene Summary: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila. [UniProtKB/Swiss-Prot Function]

Transcript Variant: This variant (2), also known as psiNAIP, lacks two internal exons in the 5' coding region, as compared to variant 1. The resulting isoform (2) has an alternate and shorter N-terminus, as compared to isoform 1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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