OriGene - RDH8 (NM_015725) cDNA Clone

OriGene Data

Vector:	pCMV6-XL	Insert Size:	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Druggable Genome
Protein Pathways:	Retinol metabolism Metabolic pathways

Reference Data

RefSeq: NM_015725.1, NP_056540	RefSeq Size: 1714	RefSeq ORF: 936
Synonyms : PRRDH; SDR28C2
LocusID: 50700	Cytogenetic: 19p13.2
Summary: All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM, Mar 2008].

TrueClone Citations:

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2, Jonas S. Jutzi, Ruzhica Bogeska, Gorica Nikoloski, Corina A. Schmid, Thalia S. Seeger, Frank Stegelmann, Sven Schwemmers, Albert Gründer, Jan C. Peeken, Monika Gothwal, Julius Wehrle, Konrad Aumann, Kamar Hamdi, Christine Dierks, Wei Wang, Konstanze Döhner, Joop H. Jansen, and Heike L. Pahl, J. Exp. Med., May 2013; 210: 1003 - 1019. [MAFG]

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase and Stimulates Its Synthetic Activity, Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E. Syväoja, Barbara van Loon, Ulrich Hübscher, and Francesca M. Pisani, J. Biol. Chem., May 2013; 288: 12742 - 12752. [TIPIN]

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals, Xueliang Gao, Haizhen Wang, Jenny J. Yang, Jing Chen, Jiang Jie, Liangwei Li, Yinwei Zhang, and Zhi-Ren Liu, J. Biol. Chem., May 2013; 288: 15971 - 15979. [PKM2]

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors a- and -mediated transactivation, Yukimasa Takeda and Anton M. Jetten, Nucleic Acids Res., May 2013; 10.1093/nar/gkt447. [Prox1 ]

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia, Hanna L. M. Rajala, Samuli Eldfors, Heikki Kuusanmäki, Arjan J. van Adrichem, Thomas Olson, Sonja Lagström, Emma I. Andersson, Andres Jerez, Michael J. Clemente, Yiyi Yan, Dan Zhang, Andy Awwad, Pekka Ellonen, Olli Kallioniemi, Krister Wennerberg, Kimmo Porkka, Jaroslaw P. Maciejewski, Thomas P. Loughran, Jr, Caroline Heckman, and Satu Mustjoki, Blood, May 2013; 121: 4541 - 4550. [STAT5B]

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites, Isabelle Bally, Sarah Ancelet, Christine Moriscot, Florence Gonnet, Alberto Mantovani, Régis Daniel, Guy Schoehn, Gérard J. Arlaud, and Nicole M. Thielens, PNAS, May 2013; 110: 8650 - 8655. [C1qA]

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension, Ryan S. Friese, Angelina E. Altshuler, Kuixing Zhang, Jose Pablo Miramontes-Gonzalez, C. Makena Hightower, Martin L. Jirout, Rany M. Salem, Jiaur R. Gayen, Nitish R. Mahapatra, Nilima Biswas, Mo Cale, Sucheta M. Vaingankar, Hyung-Suk Kim, Maïté Courel, Laurent Taupenot, Michael G. Ziegler, Nicholas J. Schork, Michal Pravenec, Sushil K. Mahata, Geert W. Schmid-Schönbein, and Daniel T. O'Connor, Hum. Mol. Genet., May 2013; 10.1093/hmg/ddt213. [HAND1]

Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO), Dirk Winkler, Maria Beconi, Leticia M. Toledo-Sherman, Michael Prime, Andreas Ebneth, Celia Dominguez, and Ignacio Muñoz-Sanjuan, J Biomol Screen, May 2013; 10.1177/1087057113489731. [KMO]

More TrueClone Citations >>

RDH8 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC212999	Mus musculus retinol dehydrogenase 8 (Rdh8) as transfection-ready DNA	10 ug	$380	4 weeks
MR222364	Myc-DDK-tagged ORF clone of Mus musculus retinol dehydrogenase 8 (Rdh8) as transfection-ready DNA	10 ug	$380	4 weeks
MG222364	GFP-tagged ORF clone of Mus musculus retinol dehydrogenase 8 (Rdh8) as transfection-ready DNA	10 ug	$420	3 weeks

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RDH8 (NM_015725) Human cDNA Clone

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RDH8 Mouse Clones

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