OriGene - KDM2A (NM_012308) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 1080	Restriction Site: NotI-NotI
Sequence Data:	5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Annotation:	This TrueClone was found to represent an alternative form of the specific reference to which it is associated. Its Open Reading Frame (ORF) may represent a novel form or alternative splice variant. By virtue of it being a true transcript (cDNA clone not PCR product), it provides a biologically relevant copy of its mRNA template. For more details, please evaluate the sequence information provided on this website or contact our customer care specialists.
OTI Disclaimer:	The sequence of an 'OriGene Unique Variant' differs significantly from the associated reference. It represents a novel splice variant from the same gene locus of the reference. Although such variants are true transcripts and present opportunity for discoveries, they are not yet curated by NCBI and should not be used if the exact reference accession sequence is required.
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Transcription Factors Druggable Genome
Protein Pathways:

Reference Data

RefSeq: NM_012308.1, NP_036440	RefSeq Size: 6210	RefSeq ORF: 3489
Synonyms : CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA
LocusID: 22992	Cytogenetic: 11q13.2	Domains: F-box, PHD, zf-CXXC, jmjC, LRR_CC
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

TrueClone Citations:

Dihydrotestosterone and Bicalutamide Do Not Affect Periostin Expression in Androgen-dependent LNCaP Prostate Cancer Cell Lines, FRANCESCA ARGELLATI, PIER VITALE NUZZO, FRANCESCO RICCI, ROSA MANGERINI, ALESSANDRA RUBAGOTTI, and FRANCESCO BOCCARDO, Anticancer Res, Mar 2013; 33: 815 - 820. [POSTN]

An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart, Eva Tritsch, Youssef Mallat, Florence Lefebvre, Nicolas Diguet, Brigitte Escoubet, Jocelyne Blanc, Leon J. De Windt, Daniele Catalucci, Grégoire Vandecasteele, Zhenlin Li, and Mathias Mericskay, Cardiovasc Res, Mar 2013; 10.1093/cvr/cvt042. [JunD]

CSF1R mutations link POLD and HDLS as a single disease entity, Alexandra M. Nicholson, Matt C. Baker, NiCole A. Finch, Nicola J. Rutherford, Christian Wider, Neill R. Graff-Radford, Peter T. Nelson, H. Brent Clark, Zbigniew K. Wszolek, Dennis W. Dickson, David S. Knopman, and Rosa Rademakers, Neurology, Mar 2013; 80: 1033 - 1040. [CSF1R ]

Induced CYP3A4 Expression in Confluent Huh7 Hepatoma Cells as a Result of Decreased Cell Proliferation and Subsequent Pregnane X Receptor Activation, Louise Sivertsson, Irene Edebert, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, and Etienne P. A. Neve, Mol. Pharmacol., Mar 2013; 83: 659 - 670. [NR1I2 ]

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members, Alexis Verger, Jean-Luc Baert, Kathye Verreman, Frédérique Dewitte, Elisabeth Ferreira, Zoé Lens, Yvan de Launoit, Vincent Villeret, and Didier Monté, Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt199. [MED25]

Centaurin-a1-Ras-Elk-1 Signaling at Mitochondria Mediates ß-Amyloid-Induced Synaptic Dysfunction, Erzsebet M. Szatmari, Ana F. Oliveira, Elizabeth J. Sumner, and Ryohei Yasuda, J. Neurosci., Mar 2013; 33: 5367 - 5374. [APP]

Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion, Henrik Dimke, Prajakta Desai, Jelena Borovac, Alyssa Lau, Wanling Pan, and R. Todd Alexander, Am J Physiol Renal Physiol, Mar 2013; 304: F761 - F769. [Cldn14]

Mechanisms by which the orexigen NPY regulates anorexigenic a-MSH and TRH, Nicole E. Cyr, Anika M. Toorie, Jennifer S. Steger, Matthew M. Sochat, Samantha Hyner, Mario Perello, Ronald Stuart, and Eduardo A. Nillni, Am J Physiol Endocrinol Metab, Mar 2013; 304: E640 - E650. [NYP1R]

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway, David R. Croucher, Falko Hochgräfe, Luxi Zhang, Ling Liu, Ruth J. Lyons, Danny Rickwood, Carole M. Tactacan, Brigid C. Browne, Naveid Ali, Howard Chan, Robert Shearer, David Gallego-Ortega, Darren N. Saunders, Alexander Swarbrick, and Roger J. Daly, Cancer Res., Mar 2013; 73: 1969 - 1980. [SGK269 ]

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KDM2A Mouse Clones

SKU	Description	Amount	Price	Shipping
MC223755	Mus musculus lysine (K)-specific demethylase 2A (Kdm2a) as transfection-ready DNA	10 ug	$1390	6 weeks
MR210889	Myc-DDK-tagged ORF clone of Mus musculus lysine (K)-specific demethylase 2A (Kdm2a) as transfection-ready DNA	10 ug	$1390	Next day

KDM2A Rat Clones

SKU	Description	Amount	Price	Shipping
RN206477	NativeORF clone of Rattus norvegicus F-box and leucine-rich repeat protein 11 (Fbxl11) as transfection-ready DNA	10 ug	$1743	6 weeks
RR206477	Myc-DDK-tagged ORF clone of Rattus norvegicus F-box and leucine-rich repeat protein 11 (Fbxl11) as transfection-ready DNA	10 ug	$1743	6 weeks

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KDM2A (NM_012308) Human cDNA Clone

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KDM2A Mouse Clones

KDM2A Rat Clones

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