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Home TrueClone WEE1 Clone

WEE1 (NM_003390) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323510 WEE1 (untagged)-Kinase deficient mutant (K328M) of Human WEE1 homolog (S. pombe) (WEE1) (10ug), NM_003390.2, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA314672 Rabbit polyclonal WEE1 (Ab-53) antibody, 100ul $325 3 Weeks
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Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL4 Insert Size: 3670 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseStem cell - PluripotencyDruggable Genome
Protein Pathways: Cell cycle
Reference Data
RefSeq: NM_003390.2, NP_003381
RefSeq Size: 4232 RefSeq ORF: 1941
Synonyms : WEE1A; WEE1hu
LocusID: 7465 Cytogenetic: 11p15.4 Domains: pkinase, TyrKc, S_TKc
Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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