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Home TrueClone STAT3 Clone

STAT3 (NM_003150) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC309567 STAT3 (untagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 2 (10ug) NM_003150.3, 10ug $1390 4 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA300379 Rabbit Monoclonal Antibody against STAT3 (Clone E121-31), 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 2700 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Transcription FactorsDruggable Genome
Protein Pathways: Chemokine signaling pathwayJak-STAT signaling pathwayAdipocytokine signaling pathwayPathways in cancerPancreatic cancerAcute myeloid leukemia
Reference Data
RefSeq: NM_003150.3, NP_003141
RefSeq Size: 4953 RefSeq ORF: 2310
Synonyms : APRF; HIES
LocusID: 6774 Cytogenetic: 17q21.31 Domains: SH2, STAT_bind
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul

Transcript Variant: This variant (2) lacks a segment in the 5' UTR and 3 nt within the CDS, as compared to variant 1. The resulting isoform (2) lacks an amino acid compared to isoform 1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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