Over 1000 citations of OriGene cDNA clones

MET Receptor Sequence Variants R970C and T992I Lack Transforming Capacity Cancer Res., Aug 2010; 70: 6233 - 6237 [MET]

Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a Mol. Pharmacol., Aug 2010; 78: 226 - 236 [ZBTB10]

Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin Am. J. Pathol., Aug 2010; 177: 1004 - 1016 [PDPN]

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2 Blood, Jul 2010; 116: 254 - 266 [RUNX1]

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RYK (NM_002958) Human Kinase Deficient Mutant

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SC323660

NM_002958

Kinase deficient mutant (K234M) of Homo sapiens RYK receptor-like tyrosine kinase (RYK), transcript variant 2 as transfection-ready DNA NM_002958.2

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Click here for the corresponding wild type clone.

OriGene TrueClone Data

Vector:	pCMV6-XL4	Insert Size: 3100	Restriction Site:
Sequence Data:	5' Read Nucleotide Sequence Kinase domain sequence
OTI Annotation:	This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_002958.2, NP_002949	RefSeq Size: 2951	RefSeq ORF: 1824
Synonyms : D3S3195; JTK5; JTK5A; RYK1
LocusID: 6259	Cytogenetic: 3q22	Domains: pkinase, TyrKc, S_TKc, WIF
Summary: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq]. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).