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Home TrueClone PTPRM Clone

PTPRM (NM_002845) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC118369 PTPRM (untagged)-Human protein tyrosine phosphatase, receptor type, M (PTPRM), transcript variant 2 (10ug), NM_002845.2, 10ug $2620 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA317225 PTPRM Goat Polyclonal (Internal) Antibody, 50ug $345 3-7 Days
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OriGene Data
Vector:pCMV6-XL4 Insert Size: 4700 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: TransmembranePhosphataseDruggable Genome
Protein Pathways: Cell adhesion molecules (CAMs)Adherens junction
Reference Data
RefSeq: NM_002845.2, NP_002836
RefSeq Size: 5065 RefSeq ORF: 4359
Synonyms : hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU
LocusID: 5797 Cytogenetic: 18p11.2 Domains: PTPc, MAM, PTPc_motif, IG, FN3
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) lacks two adjacent in-frame exons in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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