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PRKACA (NM_002730) Human cDNA Clone

Specifications Citations (2) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC125607 PRKACA (untagged)-Human protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 1, NM_002730.3, 10ug $190 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA314379 Rabbit polyclonal PKA CAT (Ab-197) antibody, 100ul $325 3 Weeks
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OriGene Data
Vector: pCMV6-XL4 Insert Size: 1800 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseDruggable Genome
Protein Pathways: MAPK signaling pathwayCalcium signaling pathwayChemokine signaling pathwayOocyte meiosisApoptosisVascular smooth muscle contractionMore Pathways >>
Reference Data
RefSeq Explanation: NM_002730.3, NP_002721
RefSeq Size: 2689 RefSeq ORF: 1056
Synonyms : PKACA; PPNAD4
LocusID: 5566 Cytogenetic: 19p13.1 Domains: pkinase, pkinase_C, TyrKc, S_TKc
Gene Summary: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015].

Transcript Variant: This variant (1) encodes Calpha1 (PMID:21812984).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping


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