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Over 1000 citations of OriGene cDNA clones

c-Jun and Ets2 Proteins Regulate Expression of Spleen Tyrosine Kinase in T Cells J. Biol. Chem., Apr 2012; 287: 11833 - 11841. [JUND ]

CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets J. Immunol., Apr 2012; 188: 3584 - 3593. [FCGR3A ]

Constitutive Expression of Inter-a-inhibitor (IaI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex J. Biol. Chem., Apr 2012; 287: 12433 - 12444. [TNFAIP6 ]

Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium Circulation, Apr 2012; 125: 1664 - 1672. [EDIL3 ]

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ZAP70 (NM_001079) Human Kinase Deficient Mutant

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Cat. No.

Ref. ID

Description

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SC323675

NM_001079

Kinase deficient mutant (K369M) of Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1 as transfection-ready DNA NM_001079.3

10ug

$680

Next day

Click here for the corresponding wild type clone.

OriGene Data

Vector:	pCMV6-XL4	Insert Size:	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence Kinase domain sequence
OTI Annotation:	This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Protein Kinase Druggable Genome
Protein Pathways:	Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Primary immunodeficiency

Reference Data

RefSeq: NM_001079.3, NP_001070	RefSeq Size: 2450	RefSeq ORF: 1860
Synonyms : FLJ17670; FLJ17679; SRK; STD; TZK; ZAP-70
LocusID: 7535	Cytogenetic: 2q12
Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Over 1000 citations of OriGene cDNA clones

ZAP70 (NM_001079) Human Kinase Deficient Mutant

ZAP70 Mouse Clones

ZAP70 Rat Clones