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RefSeq: NM_001014795.1,
NP_001014795
LocusID:
3611
Cytogenetic:
11p15.5
Summary: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Transcript Variant: This variant (3) lacks the 5' exon but has an alternate segment at the 5' end, as compared to variant 1. It encodes the same protein as variant 1.
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