Bat3 promotes the membrane integration of tail-anchored proteins J. Cell Sci., Jul 2010; 123: 2170 - 2178 [BAT3]

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AKT1 (NM_001014432) Human cDNA Clone

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Description

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SC301930

NM_001014432

Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2 as transfection-ready DNA NM_001014432.1

$480

4-5 weeks

The use of this clone has been cited in the linked publication

Also for AKT1 (NM_001014432)

OriGene TrueClone Data

Vector:	pCMV6-XL	Insert Size:	Restriction Site:
Sequence Data:	Edited Nucleotide Sequence 5' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_001014432.1, NP_001014432	RefSeq Size: 2878	RefSeq ORF: 1443
Synonyms : AKT; MGC99656; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
LocusID: 207	Cytogenetic: 14q32.32
Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (2) lacks the 5' segment, but has an upstream alternate 5' exon, as compared to variant 1. Variants 1 and 2 encode the same protein.