OriGene - EI24 (NM_001007277) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 1700	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Annotation:	The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001007277.1.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Transmembrane Druggable Genome
Protein Pathways:	p53 signaling pathway

Reference Data

RefSeq: NM_001007277.1, NP_001007278	RefSeq Size: 2167	RefSeq ORF: 789
Synonyms : EPG4; PIG8; TP53I8
LocusID: 9538	Cytogenetic: 11q24
Summary: This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) lacks one of the coding exons compared to transcript variant 1, which results in a frameshift and early transcription termination. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

TrueClone Citations:

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST, Shiteshu Shrimal, Steven F. Trueman, and Reid Gilmore, J. Cell Biol., Apr 2013; 201: 81 - 95. [CD40]

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1, Edward B. Maryon, Shannon A. Molloy, and Jack H. Kaplan, Am J Physiol Cell Physiol, Apr 2013; 304: C768 - C779. [CSS]

B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma, Robert O. Carpenter, Moses O. Evbuomwan, Stefania Pittaluga, Jeremy J. Rose, Mark Raffeld, Shicheng Yang, Ronald E. Gress, Frances T. Hakim, and James N. Kochenderfer, Clin. Cancer Res., Apr 2013; 19: 2048 - 2060. [BCMA ]

Retinoic Acid Receptor ß Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice, Yu Li, Kimberly Wong, Kenneth Walsh, Bin Gao, and Mengwei Zang, J. Biol. Chem., Apr 2013; 288: 10490 - 10504. [FGF21 ]

Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation, Naveen L. Pereira, Dong Lin, Linda Pelleymounter, Irene Moon, Gail Stilling, Bruce W. Eckloff, Eric D. Wieben, Margaret M. Redfield, John C. Burnett, Jr, Vivien C. Yee, and Richard M. Weinshilboum, Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene, Hui Wei, Tapan K. Bera, Alan S. Wayne, Laiman Xiang, Simona Colantonio, Oleg Chertov, and Ira Pastan, J. Biol. Chem., Apr 2013; 288: 12305 - 12312. [WDR85]

Arachidonic Acid–Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4-Mediated Ca2+ Entry, Xiaodong Zheng, Natalya S. Zinkevich, Debebe Gebremedhin, Kathryn M. Gauthier, Yoshinori Nishijima, Juan Fang, David A. Wilcox, William B. Campbell, David D. Gutterman, and David X. Zhang, JAHA, Apr 2013; 2: e000080. [TRPV4 ]

Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines, Urszula Oleksiewicz, Triantafillos Liloglou, Kalliopi-Maria Tasopoulou, Nikoleta Daskoulidou, Julie Bryan, John R. Gosney, John K. Field, and George Xinarianos, Hum. Mol. Genet., Apr 2013; 10.1093/hmg/ddt174. [CYGB ]

Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response, Vincentius A. Halim, Mónica Alvarez-Fernández, Yan Juan Xu, Melinda Aprelia, Henk W. P. van den Toorn, Albert J. R. Heck, Shabaz Mohammed, and René H. Medema, Sci. Signal., Apr 2013; 6: rs9. [SPAG5]

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EI24 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC208428	Mus musculus etoposide induced 2.4 mRNA (Ei24), transcript variant 2 as transfection-ready DNA	10 ug	$380	3 weeks
MR224668	Myc-DDK-tagged ORF clone of Mus musculus etoposide induced 2.4 mRNA (Ei24), transcript variant 2 as transfection-ready DNA	10 ug	$380	3 weeks
MG224668	GFP-tagged ORF clone of Mus musculus etoposide induced 2.4 mRNA (Ei24) as transfection-ready DNA	10 ug	$420	3 weeks

EI24 Rat Clones

SKU	Description	Amount	Price	Shipping
RN209112	NativeORF clone of Rattus norvegicus etoposide induced 2.4 mRNA (Ei24) as transfection-ready DNA	10 ug	$380	3 weeks
RR209112	Myc-DDK-tagged ORF clone of Rattus norvegicus etoposide induced 2.4 mRNA (Ei24) as transfection-ready DNA	10 ug	$380	3 weeks

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EI24 (NM_001007277) Human cDNA Clone

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EI24 Mouse Clones

EI24 Rat Clones

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