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Over 1000 citations of OriGene cDNA clones

Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses Cancer Prevention Research, Jan 2012; 5: 122 - 137. [HSPB1 ]

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells Mol. Cancer Res., Jan 2012; 10: 133 - 142. [SREBF1 ]

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy Cancer Res., Jan 2012; 72: 527 - 536. [AR ]

CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling J. Biol. Chem., Jan 2012; 287: 1198 - 1209. [Cnr2 ]

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TP53 (NM_000546) Human cDNA Clone

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Cat. No.

Ref. ID

Description

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SC119832

NM_000546

Homo sapiens tumor protein p53 (TP53), transcript variant 1 as transfection-ready DNA NM_000546.2

10ug

$185

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The use of this clone has been cited in the linked publication

Also for TP53 (NM_000546)

OriGene TrueORF Data

Vector:	pCMV6-XL5	Insert Size: 2560	Restriction Site: NotI-NotI
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Stem cell - Pluripotency Transcription Factors Druggable Genome
Protein Pathways:	MAPK signaling pathway Cell cycle p53 signaling pathway Apoptosis Wnt signaling pathway Neurotrophin signaling pathway More Pathways >>

Reference Data

RefSeq: NM_000546.2, NP_000537	RefSeq Size: 2629	RefSeq ORF: 1182
Synonyms : FLJ92943; LFS1; P53; TRP53
LocusID: 7157	Cytogenetic: 17p13.1	Domains: P53
Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq]. Transcript Variant: This variant (1) is a dominant transcript and encodes isoform a.

Over 1000 citations of OriGene cDNA clones

TP53 (NM_000546) Human cDNA Clone

Click here to learn about OriGene’s recombinant TP53 protein