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Home TrueClone PTEN Clone

PTEN (NM_000314) Human cDNA Clone

Specifications Citations (6) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC119965 PTEN (untagged)-Human phosphatase and tensin homolog (PTEN), NM_000314.3, 10ug $185 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA801108 PTEN mouse monoclonal antibody, clone OTI2H9 (formerly 2H9), 100ul $325 In Stock
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 2390 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: PhosphataseDruggable Genome
Protein Pathways: Inositol phosphate metabolismPhosphatidylinositol signaling systemp53 signaling pathwayFocal adhesionTight junctionPathways in cancerMore Pathways >>
Reference Data
RefSeq: NM_000314.3, NP_000305
RefSeq Size: 3416 RefSeq ORF: 1212
Synonyms : 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
LocusID: 5728 Cytogenetic: 10q23.3 Domains: PTPc_motif
Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (PTEN-L, PMID:23744781; also known as PTENalpha, PMID: 24768297) is derived from the use of an upstream non-AUG (CUG) start codon, while two shorter isoforms are derived from downstream AUG start codons. The most abundant isoform (PTEN), which is derived from the use of 5'-most AUG start codon, is represented in this RefSeq.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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