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EDNRB (NM_000115) Human cDNA Clone

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SC126607

NM_000115

Homo sapiens endothelin receptor type B (EDNRB), transcript variant 1 as transfection-ready DNA NM_000115.1

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Also for EDNRB (NM_000115)

OriGene TrueClone Data

Vector:	pCMV6-XL5	Insert Size: 4130	Restriction Site: NotI-NotI
Sequence Data:	5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_000115.1, NP_000106	RefSeq Size: 4286	RefSeq ORF: 1329
Synonyms : ABCDS; ETB; ETBR; ETRB; HSCR; HSCR2; WS4A
LocusID: 1910	Cytogenetic: 13q22	Domains: 7tm_1
Summary: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq]. Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode isoform 1.