Bat3 promotes the membrane integration of tail-anchored proteins J. Cell Sci., Jul 2010; 123: 2170 - 2178 [BAT3]

Caveolin-1 modulates HIV-1 envelope induced bystander apoptosis through gp41 J. Virol., Jul 2010; 84: 6515 - 6526 [CAV1]

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HIV infection upregulates Caveolin 1 (Cav-1) expression to restrict virus production J. Virol., Jul 2010; 10.1128/JVI.00763-10. [CAV1]

CDK4 (NM_000075) Human Kinase Deficient Mutant

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SC323699

NM_000075

Kinase deficient mutant (K35M) of Homo sapiens cyclin-dependent kinase 4 (CDK4) as transfection-ready DNA NM_000075.2

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Click here for the corresponding wild type clone.

OriGene TrueClone Data

Vector:	pCMV6-XL5	Insert Size: 1960	Restriction Site:
Sequence Data:	5' Read Nucleotide Sequence Kinase domain sequence
OTI Annotation:	This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_000075.2, NP_000066	RefSeq Size: 1474	RefSeq ORF: 912
Synonyms : CMM3; MGC14458; PSK-J3
LocusID: 1019	Cytogenetic: 12q14	Domains: pkinase, TyrKc, S_TKc
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq]. Transcript Variant: This variant (1) encodes the full length protein.