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Over 1000 citations of OriGene cDNA clones

Bat3 promotes the membrane integration of tail-anchored proteins J. Cell Sci., Jul 2010; 123: 2170 - 2178 [BAT3]

Caveolin-1 modulates HIV-1 envelope induced bystander apoptosis through gp41 J. Virol., Jul 2010; 84: 6515 - 6526 [CAV1]

Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression PNAS, Jul 2010; 107: 12210 - 12215 [PXDN]

HIV infection upregulates Caveolin 1 (Cav-1) expression to restrict virus production J. Virol., Jul 2010; 10.1128/JVI.00763-10. [CAV1]

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ACVRL1 (NM_000020) Human Kinase Deficient Mutant

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SC323433

NM_000020

Kinase deficient mutant (K229M) of Homo sapiens activin A receptor type II-like 1 (ACVRL1), transcript variant 1 as transfection-ready DNA NM_000020.1

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Click here for the corresponding wild type clone.

OriGene TrueClone Data

Vector:	pCMV6-XL5	Insert Size:	Restriction Site:
Sequence Data:	5' Read Nucleotide Sequence Kinase domain sequence
OTI Annotation:	This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_000020.1, NP_000011	RefSeq Size: 1970	RefSeq ORF: 1511
Synonyms : ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I
LocusID: 94	Cytogenetic: 12q11	Domains: Activin_recp, pkinase, TyrKc, S_TKc, GS
Summary: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.