IZUMO1 Rabbit Polyclonal Antibody

CAT#: TA349189

Rabbit Polyclonal Anti-IZUMO1 Antibody

Product Images

Western blot analysis of IZUMO1 in human testis tissue lysate with IZUMO1 antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IZUMO1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 35, 39, 42 kDa; Observed: 52 kDa
• Gene Name: izumo sperm-egg fusion 1
• Database Link:
  NP_872381
  Entrez Gene 284359 Human
  UniProt ID Q8IYV9
• Background: IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).
• Synonyms: DRLM