COX11 Rabbit Polyclonal Antibody

CAT#: TA347690

Rabbit Polyclonal Anti-COX11 Antibody

Product Images

Western blot analysis on RAW264.7 cell lysate using COX11 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-COX11 Antibody: A synthesized peptide derived from human COX11
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: COX11 cytochrome c oxidase copper chaperone
• Database Link:
  NP_004366
  Entrez Gene 69802 MouseEntrez Gene 1353 Human
  UniProt ID Q9Y6N1
• Background: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. A pseudogene COX11P has been found on chromosome 6.
• Synonyms: COX11P
• Note: COX11 Antibody detects endogenous levels of COX11

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, Oxidative phosphorylation