SPIB Rabbit Polyclonal Antibody

CAT#: TA336812

Rabbit Polyclonal Spi-B Antibody

Product Images

Western Blot: SPIB Antibody TA336812 - Analysis of Spi-B in human Daudi lysate in the 1) absence and 2) presence of immunizing peptide and 3) on mouse RAW lysate using Spi-B polyclonal antibody at 4 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 3-5 ug/ml
• Reactivities: Human, Mouse, Bovine, Canine, Equine, Primate
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acid 15-65 of human Spi-B was used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Spi-B transcription factor
• Database Link:
  NP_003112
  Entrez Gene 272382 MouseEntrez Gene 6689 Human
  UniProt ID Q01892
• Background: Transcription factor Spi-B belongs to the ETS family and contains one ETS DNA-binding domain. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression, thus maintains activity of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation. It is reported that Spi-B regulates Progressive multifocal leukoencephalopathy (PML) causing JCVirus gene expression, and may play an important role in JCV activity in the immune and nervous systems. It is also reported Spi-B is expressed in various murine and hematopoietic lines except T lymphoid lines.
• Synonyms: SPI-B

Reference Data

• Protein Families: Transcription Factors