PRMT7 Rabbit Polyclonal Antibody

CAT#: TA336349

Rabbit Polyclonal PRMT7 Antibody

Product Images

Western Blot: PRMT7 Antibody TA336349 - Analysis of PRMT7 in A) HeLa and B) NIH 3T3 cell lysate using this antibody at 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-3 ug/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acids 346-360 of human PRMT7 were used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein arginine methyltransferase 7
• Database Link:
  NP_061896
  Entrez Gene 214572 MouseEntrez Gene 54496 Human
  UniProt ID Q9NVM4
• Background: Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. The PRMT proteins are recruited by C-terminal activation domain-2 of the SRC (steroid receptor coactivator) GRIP-1, whereas p300 interacts with activation domain-1 in the C terminus. have identified a mammalian arginine N-methyltransferase, PRMT7, that can catalyze the formation of omega-NG-monomethylarginine in peptides. In contrast to the other members of the PRMT family, PRMT7 was not able to methylate GST-fibrillarin or myelin basic protein or histone H2A, in vitro. It is also structurally different from other PRMTS in containing two putative AdoMet-binding motifs. Both of these domains are required for enzymatic activity.
• Synonyms: FLJ10640; KIAA1933

Reference Data

• Protein Families: Druggable Genome