IKB zeta (NFKBIZ) Rabbit Polyclonal Antibody

CAT#: TA336346

Rabbit Polyclonal IKB zeta Antibody

Product Images

Western Blot: IKB zeta Antibody TA336346 - Analysis at 3 ug/ml in mouse RAW cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-3 ug/ml
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptides corresponding to an amino acid range between 270-320 and 670-720 of mouse IkB zeta protein were used as the immunogen for this antibody.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NFKB inhibitor zeta
• Database Link:
  NP_113607
  Entrez Gene 64332 Human
  UniProt ID Q9BYH8
• Background: IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
• Synonyms: IKBZ; INAP; MAIL

Reference Data

• Protein Families: Druggable Genome