SRCAP Goat Polyclonal Antibody

CAT#: TA329681

Goat Anti-SRCAP (aa309-322) Polyclonal Antibody

Product Images

TA329681 (5ug/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5-10ug/ml
• Reactivities: Human (Expected from sequence similarity: Mouse, Rat, Dog, Pig)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-QEGNDAEAQRREIE, from the internal region (near N Trminus) of the protein sequence according to NP_006653.2
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Snf2-related CREBBP activator protein
• Database Link:
  NP_006653
  Entrez Gene 100043597 MouseEntrez Gene 361652 RatEntrez Gene 479773 DogEntrez Gene 10847 Human
  UniProt ID Q6ZRS2
• Background: This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
• Synonyms: DOMO1; EAF1; FLHS; SWR1
• Note: IHC: In paraffin embedded Human Skin shows nuclear staining in some keratinocytes.