LAMTOR1 Rabbit Polyclonal Antibody

CAT#: TA326713

Rabbit Polyclonal LAMTOR1 Antibody

Product Images

Western blot analysis of LAMTOR1 in A431 cell lysate with LAMTOR1 antibody at 1 ug/ml.

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  Immunohistochemistry of LAMTOR1 in human small intestine tissue with LAMTOR1 antibody at 5 ug/mL.

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  Immunofluorescence of LAMTOR1 in human small intestine tissue with LAMTOR1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal LAMTOR1 antibody was raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1
• Formulation: LAMTOR1 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: LAMTOR1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 18 kDa; Observed: 18 kDa
• Gene Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
• Database Link:
  NP_060377
  Entrez Gene 66508 MouseEntrez Gene 308869 RatEntrez Gene 55004 Human
  UniProt ID Q6IAA8
• Background: LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1). The mTORC1 kinase complex is a critical component in the regulation of cell growth (2). As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3). LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4).
• Synonyms: C11orf59; p18; p27RF-Rho; PDRO; Ragulator1