ARTS1 (ERAP1) Rabbit Polyclonal Antibody

CAT#: TA326650

Rabbit Polyclonal ERAP1 Antibody

Product Images

Western blot analysis of ERAP1 in SK-N-SH cell lysate with ERAP1 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of ERAP1 in mouse brain tissue with ERAP1 antibody at 5 ug/mL.

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  Immunofluorescence of ERAP1 in mouse brain tissue with ERAP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ERAP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERAP.
• Formulation: ERAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ERAP1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 104 kDa; Observed: 105 kDa
• Gene Name: endoplasmic reticulum aminopeptidase 1
• Database Link:
  NP_057526
  Entrez Gene 80898 MouseEntrez Gene 51752 Human
  UniProt ID Q9NZ08
• Background: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1) (3). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (3,4).
• Synonyms: A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP; ERAAP1; PILS-AP; PILSAP

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein