ABHD12 Rabbit Polyclonal Antibody

CAT#: TA323296

Anti-ABHD12 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323296 (ABHD12 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323296 (ABHD12 Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323296 (ABHD12 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323296 (ABHD12 Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 96-398 amino acids of human abhydrolase domain containing 12
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: abhydrolase domain containing 12
• Database Link:
  NP_056415
  Entrez Gene 76192 MouseEntrez Gene 499913 RatEntrez Gene 26090 Human
  UniProt ID Q8N2K0
• Background: This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG); the main endocannabinoid lipid transmitter that acts on cannabinoid receptors; CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes; including neurotransmission; mood; appetite; pain appreciation; addiction behavior; and inflammation. Mutations in this gene are associated with the neurodegenerative disease; PHARC (polyneuropathy; hearing loss; ataxia; retinitis pigmentosa; and cataract); resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
• Synonyms: ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC

Reference Data

• Protein Families: Protease, Transmembrane