PTP epsilon (PTPRE) Rabbit Polyclonal Antibody

CAT#: TA321768

Anti-PTPRE Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321768 (PTPRE Antibody) at dilution 1/10 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321768 (PTPRE Antibody) at dilution 1/10, treated with fusion protein. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321768 (PTPRE Antibody) at dilution 1/10 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321768 (PTPRE Antibody) at dilution 1/10, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 15-50
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 426-689 amino acids of human protein tyrosine phosphatase, receptor type, E
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein tyrosine phosphatase, receptor type E
• Database Link:
  NP_006495
  Entrez Gene 19267 MouseEntrez Gene 114767 RatEntrez Gene 5791 Human
  UniProt ID P23469
• Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported; one of which encodes a receptor-type PTP that possesses a short extracellular domain; a single transmembrane region; and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus; and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways; cytokines induced SATA signaling; as well as the activation of voltage-gated K+ channels.
• Synonyms: HPTPE; PTPE; R-PTP-EPSILON

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane