HTR2B Rabbit Polyclonal Antibody

CAT#: TA321222

Anti-HTR2B Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 20 μg Lane: 293T cells Primary antibody: TA321222 (HTR2B Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321222 (HTR2B Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321222 (HTR2B Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: 293T cells
  IHC: 25-100
  Positive control: Human lung cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 1-58 amino acids of Human 5-hydroxytryptamine receptor 2B
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 54 kDa
• Gene Name: 5-hydroxytryptamine receptor 2B
• Database Link:
  NP_000858
  Entrez Gene 3357 Human
  UniProt ID P41595
• Background: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter; a hormone; and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin; including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution; designated Q20*) which blocks expression of this protein; and knockout studies in mice; suggest a role for this gene in impulsivity. However; other factors; such as elevated testosterone levels; may also be involved.
• Synonyms: 5-HT(2B); 5-HT2B

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction