KPNA4 Rabbit Polyclonal Antibody

CAT#: TA319674

Rabbit Polyclonal KPNA4 Antibody

Product Images

Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1ug/mL.

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  Immunocytochemistry of KPNA4 in HeLa cells with KPNA4 antibody at 2.5 ug/mL.

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  Immunofluorescence of KPNA4 in HeLa cells with KPNA4 antibody at 20 ug/mL.

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  Immunofluorescence of KPNA4 in HeLa cells with KPNA4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KPNA4 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA4.
• Formulation: KPNA4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: KPNA4 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: karyopherin subunit alpha 4
• Database Link:
  NP_002259
  Entrez Gene 16649 MouseEntrez Gene 361959 RatEntrez Gene 3840 Human
  UniProt ID O00629
• Background: KPNA4 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers. KPNA3 has been shown to be important in the TNF-α-induced nuclear import of NF-κB. It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells.
• Synonyms: IPOA3; QIP1; SRP3