IL12RB2 Rabbit Polyclonal Antibody

CAT#: TA307956

Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2)

Product Images

Sample (30 ug whole cell lysate). A:A431. B: Hep G2. 7.5% SDS PAGE. TA307956 diluted at 1:5000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:1000-1:10000
• Reactivities: Human (Predicted: Dog)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 323 and 695 of IL-12 Receptor beta2 (Uniprot ID#Q99665)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 97 kDa
• Gene Name: interleukin 12 receptor subunit beta 2
• Database Link:
  NP_001550
  Entrez Gene 489550 DogEntrez Gene 3595 Human
  UniProt ID Q99665
• Background: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
• Synonyms: RP11-102M16.1
• Note: Seq homology of immunogen across species: Dog (80%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway