PCDH12 Rabbit Polyclonal Antibody

CAT#: TA306741

Rabbit Polyclonal PCDH12 Antibody

Product Images

Western blot analysis of PCDH12 in K562 cell lysate with PCDH12 antibody at 2 ug/ml.

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  Immunohistochemistry of PCDH12 in rat lung tissue with PCDH12 antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PCDH12 antibody was raised against a 17 amino acid peptide near the amino terminus of human PCDH12.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protocadherin 12
• Database Link:
  NP_057664
  Entrez Gene 53601 MouseEntrez Gene 116808 RatEntrez Gene 51294 Human
  UniProt ID Q9NPG4
• Background: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2,289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling. This antibody is predicted to not cross-react with PCDH18.
• Synonyms: VE-cadherin-2; VECAD2

Reference Data

• Protein Families: Transmembrane