SDHB Goat Polyclonal Antibody
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Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1:8,000. WB: 0.03-0.1µg/ml. |
Reactivities | Human |
Host | Goat |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Peptide with sequence C-ATYKEKKASV, from the C Terminus of the protein sequence according to NP_002991.1. |
Formulation | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
Concentration | lot specific |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 35254 Da |
Gene Name | succinate dehydrogenase complex iron sulfur subunit B |
Database Link | |
Background | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq] |
Synonyms | CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease |
Documents
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