Fetuin A (AHSG) Rabbit Polyclonal Antibody

CAT#: DP2010

Fetuin A (AHSG) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Western Blot.
  Immunohistochemistry on frozen sections.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Human serum
• Specificity: This antibody reacts to Fetuin-A.
• Formulation: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
  State: Aff - Purified
  State: Lyophilized purified IgG
• Reconstitution Method: Restore with 0.1 ml of deionized water
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C.
  Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: alpha 2-HS glycoprotein
• Database Link:
  Entrez Gene 197 Human
  UniProt ID P02765
• Background: Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver . It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGFbeta binding to cell surface receptors.
• Synonyms: Fetuin A, AHSG, FETUA, PRO2743