AMACR Rabbit Polyclonal Antibody

CAT#: DP134-05

AMACR rabbit polyclonal antibody, Purified

Product Images

Formalin fixed paraffin embedded human tonsil stained with P504S antibody. DP134

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABC method (30 minutes at room temperature).
  Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
  Recommended Positive Control: Prostate carcinoma.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic human AMACR peptide.
• Specificity: Reacts to P504S Alpha-Methylacyl-CoA Racemace.
  Cellular Localization: Cytoplasmic.
• Formulation: < 0.1% Sodium Azide
  State: Purified
  State: Liquid purified Ig fraction
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: alpha-methylacyl-CoA racemase
• Database Link:
  Entrez Gene 23600 Human
  UniProt ID Q9UHK6
• Background: P504S (AMARC) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
• Synonyms: Alpha-methylacyl-CoA racemase, P504S