MYBPC3 (N-term) Rabbit Polyclonal Antibody

CAT#: AP52783PU-N

MYBPC3 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in mouse heart tissue lysates (35ug/lane) using MYBPC3 antibody. (N-term). This demonstrates this antibody detected the MYBPC3 protein (arrow).

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  Immunohistochemistry analysis in human heart tissue (Formalin-fixed, Paraffin-embedded) using MYBPC3 antibody. (N-term), followed by peroxidase conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/10-1/50.
  Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of Human MYBPC3.
• Specificity: This antibody recognizes MYBPC3 at N-term.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: myosin binding protein C, cardiac
• Database Link:
  Entrez Gene 17868 MouseEntrez Gene 4607 Human
  UniProt ID Q14896
• Background: MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
• Synonyms: CMH4; DKFZp779E1762; FHC; MYBP-C
• Note: Molecular Weight: 140606 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)