Inhibin beta B (INHBB) (C-term) Rabbit Polyclonal Antibody

CAT#: AP52212PU-N

Inhibin beta B (INHBB) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of INHBB Antibody (C-term) in mouse testis tissue lysates (35ug/lane). This demonstrates the INHBB antibody detected the INHBB protein (arrow).

• 

  Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with INHBB Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human INHBB
• Specificity: This antibody recognizes Human and Mouse INHBB (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: inhibin beta B subunit
• Database Link:
  Entrez Gene 16324 MouseEntrez Gene 3625 Human
  UniProt ID P09529
• Background: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
• Synonyms: Activin beta-B chain, Activin B
• Note: Molecular Weight: 45122 Da

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway