ERI2 (Center) Rabbit Polyclonal Antibody

CAT#: AP51456PU-N

ERI2 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of EXOD1 Antibody in HL-60 cell line lysates (35ug/lane). This demonstrates the EXOD1 antibody detected the EXOD1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 443-472 amino acids from the Central region of Human EXOD1
• Specificity: This antibody recognizes Human EXOD1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: ERI1 exoribonuclease family member 2
• Database Link:
  Entrez Gene 112479 Human
  UniProt ID A8K979
• Background: EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
• Synonyms: Exonuclease domain-containing protein 1, KIAA1504, MGC16943
• Note: Molecular Weight: 77401 Da