Cytochrome C Oxidase subunit VIb (COX6B1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51035PU-N

Cytochrome C Oxidase subunit VIb (COX6B1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

COX6B1 Antibody (C-term) western blot analysis in ZR-75-1, A549, NCI-H292 cell line lysates (35ug/lane).This demonstrates the COX6B1 antibody detected the COX6B1 protein (arrow).

• 

  COX6B1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COX6B1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 - 1/500.
  Immunohistochemistry on paraffin sections: 1/10 - 1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 58-86 amino acids from the C-terminal region of human COX6B1
• Specificity: This antibody reacts to COX6B1.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 10192 Da
• Gene Name: cytochrome c oxidase subunit 6B1
• Database Link:
  Entrez Gene 1340 Human
  UniProt ID P14854
• Background: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
• Synonyms: Cytochrome c oxidase subunit 6B1, COX6B1, COX6B, Mitochondria Complex IV

Reference Data

• Protein Pathways: Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease